Rimonabant increased self-reported anxiety levels during the anticipatory speech and performance phase compared with placebo. Twelve participants received oral placebo and 12 received 90 mg rimonabant. Physiological parameters, namely arterial blood pressure and heart rate, also were monitored. Subjective effects were measured by Visual Analogue Mood Scale. Participants were randomly allocated to receive oral placebo or 90 mg rimonabant in a double-blind design. We investigated the hypothesis that rimonabant, a cannabinoid antagonist/inverse agonist, would increase anxiety in healthy subjects during a simulation of the public speaking test. The plant has been in talk for long time regarding the use and legal aspect and so detailed information regarding it should be necessary. This article is a sincere effort to bring forward the possible information about the plant, its chemical constituents and uses. In India the above plant has been used in wide range of medical condition such as rabies, epilepsy, muscle spasms and for pain relief. Marijuana was first used for medical purpose in Britain in the midnineteenth century by O'Shaughnessy, a surgeon in army. On the other hand, It has also been supported to have a good and accepted pharmacological activity by literature and practical users. The plant has been blamed to have an addiction causing character. The use of this plant in medical purposes has been a long time hot topic in our fraternity. The above plant has been through many legal and medical issues all round the world. The present article deals with the pharmacognosy, pharmacology and many other aspects about the plant marijuana that is well known as cannabis.

Methysticum, Sceletium tortuosum, Withania somnifera, Zingiber officinale and Ziziphus jujuba). quinquefolius, Passiflora incarnata, Piper obovata, Matricaria recutita, Melissa officinalis, Rhodiola rosea, Scutellaria spp., Tilia americana and Valeriana officinalis), and the second part deals with exotic plants (Atractylodes macrocephala, Bacopa monnieri, Centella asiatica, Citrus spp., Clitoria ternatea, Echium amoenum, Erythrina mulungu, Morinda citrifolia, Myristica fragrans, Ocimum sanctum, Panax ginseng and P. The first part of the article is aimed at our original plants and plants cultivated in our country (Cannabis sativa, Coriandrum sativum, Crocus sativus, Eschscholzia californica, Ginkgo biloba, Humulus lupulus, Hypericum perforatum, Lavandula angustifolia, Magnolia officinalis and M. In the article presented here, there is an outline of main plants used in the treatment of anxiety and insomnia. Further research of effects of these plants and their components can offer new pharmaceuticals. Tea mixtures, tinctures, food supplements and registered medicinal products containing extracts from plants are used. Herbaceous products are frequently used even at the time being, particularly for the treatment of mild problems. There are a number of plants, which have been traditionally used for the treatment of anxiety and insomnia and these effects are frequently supported by modern trials. Thus, a great attention is being paid to the investigation of new medicines without these side effects. There are a number of products for the treatment of the anxiety, but in benzodiazepine-group anxiolytics, there is a risk of the tolerance and addiction development. and insomnia is treated with sedatives and hypnotics. Anxiolytics and antidepressants are particularly used to treat anxiety. Anxiety disorders belong to most frequently encountered mental disorders in general, since up to 25 % of the population suffers by a clinically important anxious disorder at least once in a lifetime.

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